PRIME Journal Vol.10 Issue 1

IMPROVING SKIN QUALITYWITH HYALURONIC AND SUCCINIC ACID AlexanderTurkevych, NataliaDerkach, AnnaKupriyanova, LeilaZubair,MartaTurkevych, and DanyloTurkevych discuss the findings fromtheir novel newstudycombining succinicacid to improveHAfiller results ABSTRACT Natural ageing is the result of years gone by and is called chronological ageing. At the same time, there is a thickening of the horn layer and thinning of other layers of skin. The amount of hyaluronic acid produced begins to reduce. The walls of the blood capillaries become thinner. There is a descent of the soft tissues of the face under the action of gravity. As a result of these changes, the skin loses elasticity and deep wrinkles are formed. A pervasive feature of ageing is a progressive and chronic state of systemic low-grade inflammation referred to as ‘inflammaging’. The role of various inflammatory molecules—mainly tumour necrosis factor- α (TNF- α ), interleukin- (IL-) 1b, IL-6, and transforming growth factor- β (TGF- β ) in the promotion or exacerbation of a wide range of ARDs is increasingly emerging. When a patient is injected with hyaluronic acid we re-create volume and by creating more tension more hydration is achieved. Unfortunately, the effects are temporary, short lasting and somehow HA does not re-create what is continuously disappearing. The ageing phenomenon of the face is not limited to collagen and fibroblasts but also to bone loss on which HA does not have any effect. It is well-known that collagen fibres are the main frame element of the dermis and the changes that occur with them required more detailed study. Recent studies (2016- 2018) of the regulation of the morphofunctional state of macrophages indicate the involvement of the succinate/ SUCNR1 system in the formation of the reparative (anti- inflammatory M2) macrophage phenotype. There are data that confirm the relationship of succinate/SUCNR1 signalling with the mechanisms of angiogenesis and demonstrate the universality of the angiogenic effects of the succinate/SUCNR1 system, manifested in different tissues. We show in the study that addition of hyaluronic and succinic acid in specific concentrations with the needle, cannula or roller delivery injection methods should deliver a new useful treatment against the early inflammation stage. Also direct effect of the introduction of HA+Na succinate 1.6% on the level of synthesis of endogenous growth factors that directly affect the rate of tissue regeneration and renovation was found. AESTHETIC FEATURE | INJECTABLES | 36 January/February 2020 |