PRIME Journal Vol. 12 Issue 2

On the other hand, injectables are convenient in use, but until now, most of theproducts that couldbe regarded as rejuvenating injectables were not widely used in the aesthetic field. It can be explained by the fact that considering all the pros and cons, a lot of doctors are still hesitant to use them in their practice due to various reasons. Yet, since the time when the first collagen stimulator emerged on the market, it became clear that the future of aesthetic medicine would be tightly intertwined with injectable collagen stimulators, and everyone was waiting for a product that would meet the demands while providing the necessary level of safety and convenience in use. An injectable solution to solve the problem of collagen loss One of the highlights of last year’s product debut was a presentation of the new dermal injectable GOURI at AMWC 2021. It’s an innovative collagen stimulator for skin rejuvenation and full-face lifting. GOURI is made of polycaprolactone (PCL)—a well-known in medical and aesthetic field biopolymer. What makes it so unique is that GOURI’s PCL is fully solubilized. This means that this injectable does not contain micro-particles, which dramatically minimizes any potential risk of polymer injection. Due to its fully liquid form, unlike other polymer-based injectables, GOURI cannot be considered as filler – once injected, it evenly spreads under the skin, forming a supportive matrix, which starts to stimulate fibroblasts. Consequently, fibroblasts stimulation promotes neocollagenesis and restores dermal collagen levels lost in the process of skin ageing. Support and restoration of collagen produced by our skin has a paramount necessity for deep skin rejuvenation and is a key to fundamental anti-ageing. Only constant and sufficient collagen synthesis provides truly youthful skin, prevents the appearance of wrinkles, and other markers of ageing. Return of renewed PCL PCL is not new material and has been long known among medical professionals. It’s a synthetically developed biocompatible, biodegradable, and bioresorbable polymer, which belongs to the same chemical family as poly-L-lactic acid (PLLA) and polyglycolic acid (PGA). As a non-toxic, non- allergic, and bioresorbablematerial 1 , PCL has a large range of applications, such as controlled-release drug delivery systems, tissue engineering (3D scaffolds/matrices), absorbable sutures, and much more. This diversity of applications is possible due to better viscoelastic properties compared toother polymers, whichallowthepractitioner to easilymanipulate PCL’s structure 2 . In aesthetics, PCL is used as a collagen stimulator and until now has been represented in the form of threads and dermal injectables, which consist of PCL microspheres. These products have proven their effectiveness in the stimulation of collagen production. GOURI’s PCL, while keeping this main advantage, takes polycaprolactone’s possibilities even further thanks to unique CESABP technology (Collagenesis-Enabled Solubilized Active and Biodegradable Polymer), which made PCL fully solubilized. Full solubilization of polycaprolactone allows the injector to get ridof particles, which could cause such side effects as overcorrection, nodules, or even occlusions. Figure 1 (A) Before and (B) after 2 sessions with GOURI Due to its fully liquid form, unlike other polymer-based injectables, GOURI cannot be considered as filler – once injected, it evenly spreads under the skin, forming a supportivematrix, which starts to stimulate fibroblasts. CASE STUDY | COLLAGEN STIMULATION | 44 March/April 2022 |