PRIME Journal Vol. 12 Issue 1

40 January/February 2022 | A T QVENTIS, WE TAKE inspiration from biological systems and make use of science to design products that exhibit features found in biological tissues. This is Bionic (from bion-, unit of life and -ic, like) design or biologically inspired engineering—the transfer of information from biological systems into the design of medical solutions. It is easy to understand that bionic designed products exhibit superior physical, chemical and biological compatibility and therefore are less prone to trigger side-effects; in other words, they have a high safety profile. RENÉE, a set of bionic gels, is a versatile line with concentrations ranging from 18mg HA to 28mg of HA. The RENÉE product line is composed of a set of 4 dermal fillers— RENÉE SMILE (22mg HA), RENÉE TOUCH (24mg HA), RENÉE LIFT (26mg HA) and RENÉE VOLUME (28mg HA) and the skin booster RENÉE PRIME (18mg HA). All products, including RENÉE PRIME, are formulated with crosslinked HA, with a crosslinking degree of 6% and are enriched with amino acids—glycine and proline. All RENÉE formulations are homogeneous, cohesive and true monophasic, thanks to an advanced manufacturing process, during which the HA chains are exposed to minimal mechanical and thermal stress. Rheology profile The rheology of a HA filler is crucial to understand its properties and to get the best aesthetic outcome for the patients. RENÉE family of dermal fillers has been designed to combine easy injection with good tissue integration while offering optimal lifting and volumizing effect rounded by natural, long-lasting results. Regarding the basic rheological properties (G’, G” and tan δ ) for RENÉE fillers; G’ and G” increase with the concentration of HA, as expected, so that a hydrogel with a higher concentration of hyaluronic acid also has the most pronounced volumizing effect. Tan δ is an important parameter, which gives information about the hydrogel behaviour: when tan δ < 1, it means that we are dealing with a crosslinked hydrogel having an elastic modulus (G’) higher than the viscous modulus (G”), if tan δ > 1 the gel behaves as a viscous fluid. This is the case of RENÉE PRIME, our skin booster. For the RENÉE set of fillers with concentrations ranging from 22mg HA to 28mg HA, rheological results show that tan  δ is approximately constant, with a value between 0.4 and 0.5. This shows that the formulations of RENÉE fillers are hydrogels, having a good degree of viscosity. This is why RENÉE fillers are soft, well-hydrated, easy to inject and have excellent tissue integration. The value of G’ for RENÉE fillers is carefully controlled so that it is never higher than200mPa in order to have the best combination of cohesivity, elongation and resistance for the hydrogel formulations. Thanks to an advanced manufacturing process, the RENÉE formulation hydrogels have a truly monophasic structure that, together with carefully tuned rheological properties, leads to a unique combination of cohesivity, elongation and resistance, which can be shown with a simple finger test. Qventis shares the results of a recent study evaluating the safety and efficacy of RENÉE hyaluronic acid gels for tissue augmentation and facial wrinkles PROMOTION RENÉE [BIONIC-HA]® GELS FOR FACIAL AESTHETICS WHY BIONIC DESIGN MATTERS? In conclusion, RENÉE formulations have an unparalleled rheological profile with a unique combination of elasticity, cohesivity, and stretchability. Evaluationof safetyand efficacyof RENÉEBIONICGELS Studydesign The aim of this open-label, retrospective, monocentric study was to evaluate the safety and efficacy of RENÉE hyaluronic acid gels for soft tissue augmentation and correction of facial wrinkles. The study was conducted between January 2021 and December 2021 at the Centro Medico Polispecialistico (CMP) in Pavia, Italy, by an unblinded treating investigator (TI) along with a blinded evaluating investigator (EI) who performed all safety and effectiveness assessments. Different areas of the face were treated. The investigator selected the product to use on the basis of the characteristics of the area to treat and determined the technique and injection volume based on clinical experience. No Figure 1 RENÉE family of products