PRIME Journal Vol. 11 Issue 4

prime-journal.com | September/October 2021 21 | DEXLEVO | INDUSTRY INSIDER that has decreased due to skin-ageing. As a result, the comprehensive condition of the skin is improved giving the look of a complete face ‘lift’. This is real fundamental anti-ageing. Unlike existing fillers, GOURI doesn’t have micro- particles inside it. It’s completely solubilised. As a result, GOURI spreads very easily to the surrounding areas. Plus, GOURI is suitable to use for both doctors and patients, because it stimulates collagen synthesis across the entire face from only 10 injection points. Also, it reduces side effects related to micro-particles, such as vascular compression and necrosis, granuloma formation, and skin discolouration. Furthermore, GOURI is very compatiblewith other aesthetic injectables like toxin and other skin boosters. GOURI is a new type of injectable that overcomes many limitations that we have faced on the non-surgical medical aesthetic market for a long time. About DEXLEVO Established in 2013, DexLevo (CEO: Yu-Je-Won) has manufactured polymer-based beauty aesthetic devices. DEXLEVO has a patent for CESABP technology (Collagenesis-Enabled Solubilised Active and Biodegradable Polymer Technology) that enables the regeneration of natural skin collagen without the use of micro-particles. GOURI obtained CE certification as a medical device in 2021 and plan to enter the European market in earnest from this year. Also, DEXLEVO obtained Korean GMP and ISO 13485. InKorea,DEXLEVOhavesuccessfullycompletedPhase-1 clinical trials and the Phase-2 clinical trials are in progress for the KFDA approval in 2022. CESABP technology There are a lot of hyaluronic acid-based products on the market. However, hyaluronic acid is technicallydegradable in the human body in a few days. That is, the effects of the injectionwon’t last for a long time. For this reason, some companies have made stronger hyaluronic acid dermal fillers by cross-linking the hyaluronic particles using BBDE or DVS. These cross- linked fillers are so concrete that they can survive for a long time. But, materials like BBDE or DVS can potentially be seen as hazardous. To solve this problem, biocompatible and biodegradable polymer productswere developed. Themicroparticles (the size of 20 to 50 μ m) of insolubilised polymer are dispersed in carboxymethylcellulose (CMC) gel or Glycerin liquid. There are two types of polymer products commonly used in the market, poly-lactic acid (PLA) and polycaprolactone (PCL). But, the size of these particles is so big that they sometimes get stuck in the needle. Also, there is a possibility of a blockage of veins. In addition, they should only be used on a localised area of skin since they do not spread easily. Dexlevo developed a fully solubilised biocompatible andbiodegradablePCL. This solubilisedPCL spreads easily into the extensive part of the skin. So, it won’t be necessary to inject multiple points. After injection, this dermal filler forms an extensive 3D matrix that makes it possible to last for a long timewithout phagocytosis. We call this technology CESABP (Collagenesis-Enabled Solubilized Active and Biodegradable Polymer) Technology. GOURI is a new type of injectable based on the fully solubilized PCL (Polycaprolactones), which spread naturally into the surrounding area of skin. Spreading naturally, GOURI restores the collagen synthesis that has decreased due to skin-ageing. As a result, the comprehensive condition of the skin is improved with a lifting effect. Summary As the beauty market grows enormously, the needs and tastes of consumers become more diversified. In the meantime, more and more people long for the fundamental care of the effects of ageing on their skin. However, so far, there hasn’t been a suitable product to fit with their needs. Stimulating collagen synthesis is the solution for skin-ageing. Using CESABP technology, DEXLEVO’s patented technology, GOURI restores the collagen synthesis that has decreased due to skin-ageing. As a result, the comprehensive conditionof the skin is improved. Demand for this new product that satisfies this need is expected to increase remarkably. Using CESABP technology, DEXLEVO’s patented technology, GOURI restores the collagen synthesis that has decreased due to skin-ageing.

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